Welcome to the Neuromodulation Symposium organized by the Institute for Engineering in Medicine. Neuromodulation is a rapidly-growing field, encompassing a wide spectrum of implantable and non-invasive technology-based approaches for the treatment of neurological and psychiatric disorders. Advancing the field of neuromodulation represents challenges in developing engineering methodologies, understanding mechanisms of neuromodulation at cellular and system levels, clinical translation to treat patients, and shaping the regulatory process for emerging technologies and approaches. This symposium is aimed at bringing together basic scientists, engineers, clinicians, industrial practitioners and entrepreneurs to discuss challenges and opportunities in neuromodulation. The symposium will consist of plenary presentations by leaders in academia, industry and government, and poster presentations to exchange ideas in this exciting field. The Symposium will be held immediately following the Design of Medical Devices Conference. We look forward to seeing you in Minneapolis on April 14-15, 2016.